Main Street Inn B&B

221 North Main Street , Sainte Genevieve, MO 63670 USA (Show map)


Main Street Inn has spacious, quietly elegant, unpretentious accommodations that even husbands find comfortable - no clutter and no country-cute. Built in the 1880s in the heart of historic French colonial Ste. Genevieve - Missouri's oldest town, It has been exquisitely restored. Its bright, spacious parlors, dining room (with grand piano), porches, and garden beckon visitors to stay awhile and relax. Traditional and antique furniture combine with vintage linens creating comfortable rooms with modern conveniences and state-of-the-art heating & cooling. All private baths with showers; three large whirlpool suites, one with fireplace.



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  • Guest room4.8
  • Service4.9
  • Value4.6
  • Cleanliness4.9
  • Onsite Dining4.9

Great Stay

5 on October 17, 2014

An historic inn in an historic town with a gracious hostess and comfortable, inviting accommodations. What more could you want? We will be back. Bob and Mary Frances

Very, very nice

4.4 on June 30, 2014

Kay graciously switched our room when my husband wanted a TV in the room. The breakfast was great. The antique decor was wonderful. The whole experience was great. I want to return again.

Great weekend!

5 on December 21, 2013

A wonderful hidden gem. Relaxing, quiet, the proprietors are attentive to every detail.

Clean and cozy

5 on January 19, 2011

This place is quiet and unbelieveably clean. Bed was comfortable and the bedding was crisp with weighty cozy!! I found it charming and in a great location. Hosts were hospitable and helpful and at the same time respected our privacy. We loved breakfast. I might suggest a little classical music to add to the charm, I love a mood setter :) If you want charming, cozy and super super clean..this is the place and we will return! Jim & Mindy

Main Street B&B

4.8 on November 07, 2010

Very flexible in adjusting reservations. Large, comfortable rooms. Great breakfast. Innkeepers were friendly and very accomodating.

foodie's dream!

5 on August 20, 2010

Me and my husband stayed the night and had a wonderful experience. Great place for a foodie like me! Breakfast was wonderful and decadant. We enjoyed the hospitality immensely. The owners that evening pointed us in the direction of some great local restaurants. Only thing of the trip I would take back, is taking advice from the visitor center in town.They pointed us to lunch at the Brick House before checking in, food was so blah and disapointing. Our hosts at the B&B mentioned that evening right across the street is a wonderful lunch cafe' with a mouthwatering menu. Take their advice on restaurants- I so wish we would have known to ask.

Do not miss breakfast!

5 on August 10, 2010

Well, the fresh summer vegetable frittata got the day off to a great start and the company at breakfast was inspiring . The inn was very comfortable, coffee in the morning, wine in the evening, sunset on the porch after a long day of hard work visiting wineries-life is hard, then doing it all over the next day only with a fresh peach puff pastry and lovely slices of sauteed local pork. I cook for a living and this was a nice vacation. Thank-you

Best Bed and Breakfast Around

5 on June 19, 2010

My boyfriend and I stayed at the Main Street Inn B&B this weekend and it was amazing. Karen and Ken were wonderful inn keepers. Extremely friendly and they shared their knowledge of Ste. Genevieve and how they came to be in the town. The rooms were just beautiful. A wonderful step back in time. Beautifully decorated and some the of nicest little touches from the jar of pretzels they leave for you to the miniature rubber ducky on the tub. Large, open rooms that were comfortable and quiet and made you feel like you were at home. If you wanted a late night cup of coffee or tea it was available. Early morning coffee presented was most appreciated. Breakfast was outstanding. A large pastry puff with roasted apples and cranberries and custard with a carmel sauce. Breakfast slices of smoked pork. Juice, coffee, tea. Just awesome. This place has charm oozing around every corner from the moment you enter. Elegant palors inside and country setting porch on the outside off of the second floor. Great place to sit and enjoy that early morning coffee before breakfast. I can't say enough good things about the Inn. You will just have to stay there and see for yourself. Carol and Gerry

Pleasent Stay

4.0 on July 05, 2009

This B&B is located on the North end of Main Street. Slightly out of the higher traffic area of St. Gen. but close enough to walk to the restaurants and antique shops. Good food for breakfast and clean rooms. Nice garden area. Excellent hosts.

great time

5 on June 28, 2008

We stayed 2 nights at the main street inn in june. Ken & Karen were excellent hosts. The rooms were very clean and the service was outstanding. Karen served delicious breakfasts both mornings and then joined us for stimulating conversations. I would not hesitate to stay there in the future. Terry

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Location Type

National Historic District, Countryside, Small town, Village


St. Louis, MO (STL-Lambert-St. Louis Intl.) 80 miles

Directions to property:

60 miles south of St. Louis on I-55 to exit 150, MO Hwy 32 east. 5 miles into town; 32 becomes 4th St in historic area. Follow 4th to Washington, turn right, 3 blocks to N. Main. Inn is at the corner of N. Main & Washington.

Area Attractions

Art Galleries, Gourmet/Fine Dining, Museum, Nature area

Inn Details

Establishment type

Bed and Breakfast, Historic Inn

On-site amenities

Board games, Conference Rooms, Desk, Fax Machine, Library, Piano, Telephone, Videos

Room amenities

Air conditioning, Alarm clock, Amenities Basket, Ceiling fans, Fireplace, Hot tub/whirlpool tub, Radio, Satellite/Cable TV, VCR, Wi-Fi, Wired internet

On-site activities

Bicycle riding trails, Bird watching, Boating, Golfing, Hiking trails, Wine Tasting, Historic Home Tours, Shopping, Sight-seeing, Swimming pool, Tennis courts

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  • Check In:: After 4:00 pm
  • Check Out:: Noon
  • Open All Year Round: Yes
  • Smoking Allowed: Outside only Outside only
  • Drinking Allowed: Yes
  • Alcohol Provided No
  • Suitable For Children: Limited Age 12 and above
  • Childcare Provided: No
  • Guest Pets Allowed: No
  • Disabled Access No

Terms and Conditions

  • Minimum Stay: Two nights on holiday weekends & during special events
  • Accepted payments AMEX, VISA, Discover, Mastercard, Personal checks, Travelers checks, Cash
  • Deposit Amount Required: Reservations are guaranteed by credit card authorization or receipt of a check for the first night's stay.
  • Cancellations: Deposits are refundable with up to seven days advance notice of cancellation. Late arrivals should be arranged in advance.



Kay Cook

Languages spoken


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  • Time Served: 9 - 10 am
  • Serving Location: Dining Room

Special meal options

Low fat , Restrictive , Vegetarian , special diet-request

Signature Dish

Apricot filled French Toast with Caramel Pecans
Amazingly light version of a decadent French Toast. Garnished with seasonal fresh fruit and herbs and served with locally-smoked baked sausage.